reference ido1 inhibitor epacadostat Search Results


reference ido1 inhibitor epacadostat  (BPS Bioscience)
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BPS Bioscience reference ido1 inhibitor epacadostat
Effect of the investigated lichen extracts and reference compounds on the activity of indoleamine-2,3-dioxygenase <t> (IDO1, </t> IDO2) and tryptophan-2,3-dioxygenase (TDO).
Reference Ido1 Inhibitor Epacadostat, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ido1 inhibitor  (Boehringer Ingelheim)
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Boehringer Ingelheim ido1 inhibitor
<t>IDO1</t> is expressed in head and neck tumor cell lines. (A) Western blot analysis for IDO and GAPDH for human HPV+ cell lines as well as in a mouse HPV+ cell line (MEERL). The 293T cells spiked with human or mouse IDO1 served as a positive control. (B) A representative image of an MEERL tumor showing the co-localization of the IDO1 with the tumor. (C) RT-PCR analysis of IDO1 mRNA expression from hind limb MEERL tumors that were treated or not with a single dose of 10 Gy radiation 24 hours prior to tissue collection, n = 6 to 7 mice/group. Mean ± SEM, * P < .05. HEE indicates human tonsil epithelial cells transfected with E6 E7; HPV, human papilloma virus; HTE, human tonsil epithelial cells; IDO, indoleamine 2,3-dioxygenase; MEERL, mouse tonsil epithelial cells with E6, E7, h-RAS, and luciferase; mRNA, messenger RNA; MTE, mouse tonsil epithelial cells; RT-PCR, reverse transcription-polymerase chain reaction; SCC, squamous cell carcinoma.
Ido1 Inhibitor, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ido1 inhibitor/product/Boehringer Ingelheim
Average 90 stars, based on 1 article reviews
ido1 inhibitor - by Bioz Stars, 2026-04
90/100 stars
  Buy from Supplier

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Effect of the investigated lichen extracts and reference compounds on the activity of indoleamine-2,3-dioxygenase (IDO1, IDO2) and tryptophan-2,3-dioxygenase (TDO).

Journal: Pharmaceuticals

Article Title: Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective Properties

doi: 10.3390/ph14121293

Figure Lengend Snippet: Effect of the investigated lichen extracts and reference compounds on the activity of indoleamine-2,3-dioxygenase (IDO1, IDO2) and tryptophan-2,3-dioxygenase (TDO).

Article Snippet: Inhibitory effects of the investigated extracts and standards (salazinic acid, evernic acid, (−)-usnic acid), as well as the reference IDO1 inhibitor (epacadostat) were determined using Universal IDO1/IDO2/TDO Inhibitor Screening Assay Kit from BPS Bioscience, Inc. (San Diego, CA, USA).

Techniques: Activity Assay, Inhibition

The biological activity of lichen-derived compounds and extracts: compounds ( A ) and extracts ( B ), expressed by the surface of area, taking into account the measured biological properties expressed in %. The graphs were made for the concentrations: inhibition of IDO1 100.0 µg/mL ( A , B ); inhibition of COX-2 250.0 µg/mL ( A , B ); inhibition of hyaluronidase 500.0 µg/mL ( A , B ); inhibition of SOD 537.6 µg/mL ( A , B ); inhibition of GR 444.4 µg/mL ( A , B ); inhibition of GPx 243.9 µg/mL ( A , B ); cytotoxicity expressed as % of cell death: A-172 100 µM ( A ), 50 µg/mL ( B ), and T98G 100 µM ( A ), 50 µg/mL ( B ).

Journal: Pharmaceuticals

Article Title: Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective Properties

doi: 10.3390/ph14121293

Figure Lengend Snippet: The biological activity of lichen-derived compounds and extracts: compounds ( A ) and extracts ( B ), expressed by the surface of area, taking into account the measured biological properties expressed in %. The graphs were made for the concentrations: inhibition of IDO1 100.0 µg/mL ( A , B ); inhibition of COX-2 250.0 µg/mL ( A , B ); inhibition of hyaluronidase 500.0 µg/mL ( A , B ); inhibition of SOD 537.6 µg/mL ( A , B ); inhibition of GR 444.4 µg/mL ( A , B ); inhibition of GPx 243.9 µg/mL ( A , B ); cytotoxicity expressed as % of cell death: A-172 100 µM ( A ), 50 µg/mL ( B ), and T98G 100 µM ( A ), 50 µg/mL ( B ).

Article Snippet: Inhibitory effects of the investigated extracts and standards (salazinic acid, evernic acid, (−)-usnic acid), as well as the reference IDO1 inhibitor (epacadostat) were determined using Universal IDO1/IDO2/TDO Inhibitor Screening Assay Kit from BPS Bioscience, Inc. (San Diego, CA, USA).

Techniques: Activity Assay, Derivative Assay, Inhibition

IDO1 is expressed in head and neck tumor cell lines. (A) Western blot analysis for IDO and GAPDH for human HPV+ cell lines as well as in a mouse HPV+ cell line (MEERL). The 293T cells spiked with human or mouse IDO1 served as a positive control. (B) A representative image of an MEERL tumor showing the co-localization of the IDO1 with the tumor. (C) RT-PCR analysis of IDO1 mRNA expression from hind limb MEERL tumors that were treated or not with a single dose of 10 Gy radiation 24 hours prior to tissue collection, n = 6 to 7 mice/group. Mean ± SEM, * P < .05. HEE indicates human tonsil epithelial cells transfected with E6 E7; HPV, human papilloma virus; HTE, human tonsil epithelial cells; IDO, indoleamine 2,3-dioxygenase; MEERL, mouse tonsil epithelial cells with E6, E7, h-RAS, and luciferase; mRNA, messenger RNA; MTE, mouse tonsil epithelial cells; RT-PCR, reverse transcription-polymerase chain reaction; SCC, squamous cell carcinoma.

Journal: International Journal of Tryptophan Research : IJTR

Article Title: Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus–Related Head and Neck Cancer

doi: 10.1177/1178646919872508

Figure Lengend Snippet: IDO1 is expressed in head and neck tumor cell lines. (A) Western blot analysis for IDO and GAPDH for human HPV+ cell lines as well as in a mouse HPV+ cell line (MEERL). The 293T cells spiked with human or mouse IDO1 served as a positive control. (B) A representative image of an MEERL tumor showing the co-localization of the IDO1 with the tumor. (C) RT-PCR analysis of IDO1 mRNA expression from hind limb MEERL tumors that were treated or not with a single dose of 10 Gy radiation 24 hours prior to tissue collection, n = 6 to 7 mice/group. Mean ± SEM, * P < .05. HEE indicates human tonsil epithelial cells transfected with E6 E7; HPV, human papilloma virus; HTE, human tonsil epithelial cells; IDO, indoleamine 2,3-dioxygenase; MEERL, mouse tonsil epithelial cells with E6, E7, h-RAS, and luciferase; mRNA, messenger RNA; MTE, mouse tonsil epithelial cells; RT-PCR, reverse transcription-polymerase chain reaction; SCC, squamous cell carcinoma.

Article Snippet: Indoleamine 2,3 dioxygenase inhibition was achieved by chronic administration of either a nonspecific competitive inhibitor of the enzyme, 1-methyl tryptophan (Sigma-Aldrich, Saint-Louis, Missouri, USA; catalog numbers 447439 and 860646), or a selective IDO1 inhibitor (hereafter referred to as IDOInh; kindly provided by Boehringer Ingelheim, Ingelheim, Germany).

Techniques: Western Blot, Positive Control, Reverse Transcription Polymerase Chain Reaction, Expressing, Transfection, Virus, Luciferase, Reverse Transcription, Polymerase Chain Reaction

Genetic deletion of host IDO1 increases tumor growth without a significant impact on behavior. (A and B) WT and ido1 −/− mice were injected with MEERL tumor cells and were treated with CRT. Ido1 −/− mice displayed poorer tumor control as indicated by a trend toward larger tumors and no significant change in burrowing behavior. CRT indicates concurrent cisplatin and radiotherapy; IDO, indoleamine 2,3-dioxygenase; MEERL, mouse tonsil epithelial cells with E6, E7, h-RAS, and luciferase; WT, wild type.

Journal: International Journal of Tryptophan Research : IJTR

Article Title: Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus–Related Head and Neck Cancer

doi: 10.1177/1178646919872508

Figure Lengend Snippet: Genetic deletion of host IDO1 increases tumor growth without a significant impact on behavior. (A and B) WT and ido1 −/− mice were injected with MEERL tumor cells and were treated with CRT. Ido1 −/− mice displayed poorer tumor control as indicated by a trend toward larger tumors and no significant change in burrowing behavior. CRT indicates concurrent cisplatin and radiotherapy; IDO, indoleamine 2,3-dioxygenase; MEERL, mouse tonsil epithelial cells with E6, E7, h-RAS, and luciferase; WT, wild type.

Article Snippet: Indoleamine 2,3 dioxygenase inhibition was achieved by chronic administration of either a nonspecific competitive inhibitor of the enzyme, 1-methyl tryptophan (Sigma-Aldrich, Saint-Louis, Missouri, USA; catalog numbers 447439 and 860646), or a selective IDO1 inhibitor (hereafter referred to as IDOInh; kindly provided by Boehringer Ingelheim, Ingelheim, Germany).

Techniques: Injection, Control, Luciferase

Genetic deletion of host IDO1 increases tumor growth without a significant impact on behavior. (A and B) WT and ido1 −/− mice were injected with MEERL tumor cells and the tumor was allowed to grow, untreated. Ido1 −/− mice displayed more rapid tumor growth. While both WT and ido1 −/− mice displayed deficits in voluntary home cage wheel running, there were no differences in tumor-induced deficits between the genotypes. (C) Analyses of mRNA expression of inflammatory markers in the liver and brain show an attenuation of tumor-induced liver IL-6, IL-1β, and Itgam/CD11b in ido1 −/− mice. n = 5-10 mice/group. * P < .05. IDO indicates indoleamine 2,3-dioxygenase; MEERL, mouse tonsil epithelial cells with E6, E7, h-RAS, and luciferase; WT, wild type.

Journal: International Journal of Tryptophan Research : IJTR

Article Title: Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus–Related Head and Neck Cancer

doi: 10.1177/1178646919872508

Figure Lengend Snippet: Genetic deletion of host IDO1 increases tumor growth without a significant impact on behavior. (A and B) WT and ido1 −/− mice were injected with MEERL tumor cells and the tumor was allowed to grow, untreated. Ido1 −/− mice displayed more rapid tumor growth. While both WT and ido1 −/− mice displayed deficits in voluntary home cage wheel running, there were no differences in tumor-induced deficits between the genotypes. (C) Analyses of mRNA expression of inflammatory markers in the liver and brain show an attenuation of tumor-induced liver IL-6, IL-1β, and Itgam/CD11b in ido1 −/− mice. n = 5-10 mice/group. * P < .05. IDO indicates indoleamine 2,3-dioxygenase; MEERL, mouse tonsil epithelial cells with E6, E7, h-RAS, and luciferase; WT, wild type.

Article Snippet: Indoleamine 2,3 dioxygenase inhibition was achieved by chronic administration of either a nonspecific competitive inhibitor of the enzyme, 1-methyl tryptophan (Sigma-Aldrich, Saint-Louis, Missouri, USA; catalog numbers 447439 and 860646), or a selective IDO1 inhibitor (hereafter referred to as IDOInh; kindly provided by Boehringer Ingelheim, Ingelheim, Germany).

Techniques: Injection, Expressing, Luciferase